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EKG Analysis: Detecting the Prolonged QT Interval Observed in Long QT Syndrome Carriers
___The defining characteristic of a person with long QT syndrome is that they demonstrate a prolonged QT interval on their EKG. Therefore, any person even vaguely suspected of having long QT syndrome must be given a 12-lead EKG and have their QT interval analyzed. Since over 75% of long QT syndrome carriers are identified by EKG analysis, it is absolutely critical that a physician knows how to evaluate a patient's EKG carefully for the signs of long QT syndrome.

___In analyzing a suspected patient's EKG there are two key elements to look for. The first, and most important, is the duration of their corrected QT interval (QTc). The second dimension of analysis involves checking for any abnormalities in the shape of their T wave.

EKG Measurements___Measuring a patient's QTc is generally a simple procedure, however it is critical that it is performed carefully. To measure a patient's QTc, it is first necessary to determine the length of the QT interval. This is generally done on lead II or another limb lead with a well defined isoelectric point. The QT interval is the time in milliseconds (ms) between the start of the QRS complex and the end of the T wave where it intersects the isoelectric point. Having measured the QT interval, the RR interval is established by measuring the time interval between the QRS peaks of two adjacent heartbeats. Computerized measurements should not be used as they are often prone to errors and not accurate enough to meet the needs of diagnosing long QT syndrome.

QTc Measurement___The QTc can be calculated using the equation shown in the figure to the right. The QTc intervals taken from at least three different T waves should be calculated. The QTc values obtained can then be used to establish the probability that a patient has long QT syndrome based on the data in table 1.

QTc Measurement EKG Classification Chance Patient has LQTS*
QTc > 460 ms Prolonged QT 95 %
460 ms > QTc > 420 ms Borderline QT 5 %
QTc < 420 ms Normal QT Less than 1 %
Table 1. Probability that an individual has long QT syndrome based on their QTc measurement.
*LQTS = Long QT Syndrome

___Aside from measuring a patient's QTc, it is also important to pay attention to the shapes of the T waves present on a patient's EKG. Remember that the T wave represents ventricular repolarization during a heartbeat and that long QT syndrome is characterized by an abnormality of this part of the heart's recharging system. With that in mind, any abnormally shaped T waves should be noted. In particular, slowly generated, notched, low amplitude, delayed, and sinusoidal T waves should be looked for.

___If a patient suspected of having long QT syndrome is found to have either a QTc above 420ms or an abnormally shaped T wave, they must be immediately referred to an experienced cardiologist for further evaluation. It becomes the cardiologist's job to further evaluate the patient and start treatment. If an immediate appointment can not be setup for a patient to see a cardiologist, the physician should send the patient's EKGs, medical records, and interview notes to the cardiologist for prompt review. The cardiologist should review the data and recommend treatment options that the physician can start the patient on prior to further evaluation. For more information about current treatments for long QT syndrome, please see the treatment section of our website by clicking here.

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