Validation of the PCR-dHPLC

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long-qt-syndrome

Validation of the PCR-dHPLC methodology for fast identification of Candida glabrata phylogenetically associated species in several organic matrices. Since two new species phylogenetically associated to Candida glabrata with barely completely different phenotypes and antifungal susceptibility profiles have been described, it appears to be crucial from medical viewpoint, to develop a fast and correct identification system with […]

Development of a new DHPLC assay

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long-qt-syndrome

Growth of a brand new DHPLC assay for genotyping UGT1A (TA)n polymorphism related to Gilbert’s syndrome. BACKGROUND Gilbert’s syndrome is the commonest hereditary dysfunction of bilirubin metabolism. The causative mutation in Caucasians is sort of solely a (TA) dinucleotide insertion within the UGT1A1 promoter. Affected people are homozygous for the variant promoter and have 7 TA repeats […]