Development of a new DHPLC assay

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long-qt-syndrome

Growth of a brand new DHPLC assay for genotyping UGT1A (TA)n polymorphism related to Gilbert’s syndrome. BACKGROUND Gilbert’s syndrome is the commonest hereditary dysfunction of bilirubin metabolism. The causative mutation in Caucasians is sort of solely a (TA) dinucleotide insertion within the UGT1A1 promoter. Affected people are homozygous for the variant promoter and have 7 TA repeats […]

Application of DHPLC screening TGFBR-3 gene

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long-qt-syndrome

[Application of DHPLC screening TGFBR-3 gene in Chinese women with idiopathic premature ovarian failure].  OBJECTIVE To judge scientific worth of denaturing excessive efficiency liquid chromatography (DHPLC) utilized in detecting remodeling development issue beta receptor 3 (TGFBR-3) exons 11 and 12 polymorphism in ladies with idiopathic untimely ovarian failure (POF). METHODS From Feb. 2009 to Dec. 2011, 110 […]